Pulsed electromagnetic field therapy has long been used to treat ailments such as non-union fractures and depression but has been showing promise in the treatment of viral infections and other illnesses. In this article we will explore it's use in promoting communication across the NAD - ATP chain.
ATP and NAD+ are classic intracellular metabolites with center-stage roles in energy metabolism and electron transfer, crosstalk between Mitochondria and Nucleus is dependent on three genes, Sirtuin, mTOR and LINE-1...Long interspersed nuclear elements.
As long as there is cross-talk between nucleus and mitochondria cells have perfect function, and diseases of the ageing process would not occur or be reduced to a minimum.
Cross-talk occurs between mitochondria and nucleus via a protein known as VDAC or voltage dependent anion channels on the outer membrane and relies on the integrity of the inner membrane, if it is damaged or disrupted the nuclear axis would not work, so the recovery of this axis is essential.
All cellular instructions that come from the nucleus are supervised by the Mitochondria which control all the cells functions. The most important functions of VDAC are Autophagy, Apoptosis and the regulation of insulin receptors of the cell membrane. These functions are done via the mitochondrial nuclear axis. Disturbance of this axis leads to ageing problems and cancer.
There are two paths of communication between mitochondria and nucleus, the antegrade axis and the retrograde axis, the retrograde being of most importance against the ageing process.
The antegrade axis is harder to control as it depends on lifestyle changes, body weight etc, but here we can see the benefits of using supplements:
The genes of the antegrade system are sirtuin, mTOR and Line-1.
Sirtuins: Sirtuins play a vital role in sustaining genome integrity. They take part in maintaining normal chromatin condensation state, in DNA damage response and repair, modulating oxidative stress and energy metabolism. They can be activated by increasing NAD via exercise, intermittent fasting, nmn, trans-resveratrol or curcumin.
mTOR: Mechanistic target of rapamycin, sometimes refered to as mammalian target of rapamycin. The mTOR pathway can be regulated with the prescription drug Metformin or supplements such as Berberine. Recommended doses of Berberine are around 900mg per day, taken in two separate doses.
LINE-1 Retrotransponsons: This is a subject all of it's own and I will aim to cover it in more detail in a future series. The important thing to understand for the purpose of this series are what Transponsons are and how they can be regulated. Transponsons, otherwise known as jumping genes, are undesireable as they are a major source of mutations. The subject itself is way too complex to go into at this stage but my cursory investigation led me to take Cayenne supplements to inhibit their activity. Readers are encouraged to do their own research in deciding if they wish to supplement or ignore. I mention them here for their rellevance in the antegrade axis, LINE-1 Retrotransponders are of immense interest to me in the field of longevity but I have much to learn about them before drawing conclusions.
More information can be found here:
My current experience of taking Cayenne supplements is that a doseage of 450mg is more than enough but I believe this shouldn't be taken every day as it seems to weaken the immune system. This could be useful on days when incorporated with PEMF and Infra Red treatment. I will update my experience in due course.
Supplements for the Retrograde axis are:
Alpha Lipoic Acid, NAC, Taurine (antioxidants)
Lysine
Arginine
Zinc
Methylsulfonylmethane (MSM)
Carnitine
